In vivo pharmacokinetics
The study formulations are dosed to study animals (mouse or rat) and plasma samples are collected and analyzed by UPLC/MS/MS.
Test concentrations: 1
Time points: 8
Replicates: 3
UPLC/MS/MS analysis
Background
In in vivo DMPK studies, compounds are administered to rodents and samples collected over a pre-defined time period. The dosing regimen and sampling are designed according to the project needs and prior information available on the study compounds, and the concentration-time data can be summarized using non-compartmental analysis (NCA) or compartmental modelling. Several options are available for bioanalytics, and the methods are always optimized for the study compounds instead of using generic methods. Furthermore, when LC/HR-MS is used, the same data can be used later for metabolite identification and profiling.
