Dynamic vapor sorption

Dynamic vapor sorption (DVS), to determine water uptake and release and related changes in crystallinity, crystal form, solvent content and morphology.
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Sorption – desorption pattern, XRPD pattern overlay, TGA comparison, microscopy images

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Background

Hygroscopicity determination and classification according USP ranges. The stability under humidity determines the handling and storage conditions of the solid. The hygroscopicity will be classified based on EP 5.11. Possible conversion is determined by comparison XRPD, TGA-DSC and optical microscopy.

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