Binding kinetics, BLI
Characterization of the Fc fragment binding of the test item to neonatal Fc receptor(s) using Bio-Layer Interferometry on Octet Red 384 instrument. Test item is delivered by the Sponsor.
Background
Surface plasmon resonance (SPR) and bio-layer interferometry (BLI) are label-free techniques which are used to investigate biomolecular interactions. They are especially suitable for characterizing antibody-antigen interactions and Fc-related antibody-effector interactions. In these techniques, the ligand is captured on the biosensor surface and binding of the analyte is investigated and information on the association and dissociation kinetics is obtained.
