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  • In vitro Metabolism
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  3. Cardiotoxicity, hERG channel blockage
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Cardiotoxicity, hERG channel blockage

The test compound is tested for its ability to block hERG potassium channel by Predictor™ Fluorescence Polarization Assay (Life Technologies).
check Protocol

Test concentrations: 16

Time points: 2 - 24 h

Replicates: 1

Positive control

Fluorescence analysis

check Deliverables

hERG channel blockage potential as IC50 value

check Reporting

Excel report
(full report available per request)

Background

Cardiotoxicity is one of the main reasons for safety-related compound attrition and drug withdrawals, and therefore should be screened in the early stages of drug discovery. We offer a cost-efficient and rapid screening tool for evaluating cardiotoxicity as a part of our toxicity screening portfolio. Full electrophysiological cardiac safety panel is available via a partner.

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Admescope

Admescope is a preclinical contract research organization (CRO) providing tailor-made ADME-Tox (Absorption, Distribution, Metabolism, Excretion and Toxicity) services for drug discovery and development companies.

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